assessment of the cytotoxic effect of a series of 1,4-dihydropyridine derivatives against human cancer cells

Authors

nima razzaghi-asl department of medicinal chemistry, school of pharmacy, ardabil university of medical sciences, ardabil, iran

ramin miri medicinal and natural products chemistry research center, shiraz university of medical sciences, shiraz, iran

omidreza firuzi medicinal and natural products chemistry research center, shiraz university of medical sciences, shiraz, iran

abstract

cancer is a leading cause of death worldwide. despite the availability of several chemotherapeutic drugs, there is still a great need for more efficient agents for a better management of cancer. in this contribution, a series of 11 dhps (4a, 4b & 7a-i) were synthesized and evaluated for their cytotoxic effect against mcf-7, ls180, and molt-4 cancer cell lines using mtt assay. synthesized 2,6-dimethyl-3,5-bis-n-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridines exhibited different potencies ranging from weak to good cytotoxic activities, while no activity could be recorded for 1,4-bis(2,6-dimethyl-3,5-dimethoxylcarbonyl-1,4-dihydropyridine-4-yl) benzene compounds (4a & 4b). tested dhp derivatives were more potent against molt-4 cells, when compared to ls180 and mcf-7 cells. compounds 7d (ic50=28.5±3.5 µm), 7a (ic50=29.7±4.7 µm) and 7a (ic50=17.4±2.0 µm) were the most potent derivatives against mcf-7, ls180 and molt-4 cells, respectively. it appeared that the introduction of n-thiazolyl carbamoyl group at the c3 and c5 positions of dhp ring enhanced the cytotoxic potential of these derivatives (compounds 7a-e). the findings of this study suggest that some of the thiazole substituted 1,4-dhps may be candidates for further modifications towards the discovery of potent antitumoral agents.

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Journal title:
iranian journal of pharmaceutical research

جلد ۱۵، شماره ۳، صفحات ۴۱۳-۴۲۰

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